Human Papilloma Virus: Current Treatment

The researchers found that the cure rate for the two techniques were practically identical: rates of 64% and 54% were observed with optical maser vaporization and cryotherapy respectively. The 10% difference amidst the two rates turn up not to be statistically substantive.

Only the success rate observed with the combined lesions proved significantly different. Residual disease encountered after either laser vaporization or cryotherapy in patients with combined lesions was 37.0% and 78.9% respectively. This corresponded to an overall success rate of 40%.

Yliskoski et al. (1989) then examined the effects of the different therapies on the different types of HPV lesion (i.e., HPV6, 11, 16, 18, 31, and 33). They found, however, that the number of subjects in their study was too bitty to draw whatsoever reliable conclusions in this regard.

Finally, they as well as observe that the cure rates achieved with two cryotherapy and laser give-and-takes were significantly high than their observed rate of spontaneous regression. Therefore, the researchers concluded that either treatment will significantly alter the clinical course of genital HPV infections. They also noted that, although cryotherapy and laser vaporization are both classified as destructive treatment modes, they can be employed as outpatient procedures; this makes them highly feasible (8:623).

The results of Yliskowsky et al. (1989) obviously tolerate the applicat

3. Mohanty, K. C.; Lowe, J. W. Cold coagulation therapy in the treatment of histologically diagnosed subclinical human papilloma virus (HPV) infection of the cervix. British Journal of Clinical Practice. 45:102104; 1991, Summer.

1. Bernstein, E. F.; Glass, J. M.; DeGraff, W. G.; Schlegel, R.; Black, C.; Fisher, J. M.; Cook, S. N.; Glatstein, E.; Russo, A.; Mitchell, J. B. In vitro photodynamic treatment of normal and human papilloma virustransfected keratinocytes with photofrin II and red light. Archives of Dermatology. 127:683687; 1991.

The study cohort included a total of 50 patients. Each had an abnormal PAP glaze over and histological evidence of cervical HPV infection with or without CIN commemorate I.

Undoubtedly, the results of the studies are reproducible. Perhaps Yliskoski's recommendations for further research might also pertain to Ruge's work. Yliskoski et al. (1989) describes the need for more patients and longer followup to more fully establish the efficacy of destructive treatments (8:624). In Ruge et al. (1992), only 50 subjects were observed over the course of 12 months (6:172). If both authors were to investigate these techniques at greater length, they might maybe arrive at a consensus.

Thus, the doubleblind, placebocontrolled trial showed that, in contrast to previous studies, systemic IFNalpha has no significant effect on the outcome of genital HPV infections (7:58). Furthermore, although the IFNtreated assembly showed a greater response against HPV16 at workweek 8, the number of patients in each subgroup was too small for any accurate analysis of the different HPV types.

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